Vacancy Details: Postdoctoral Research Scientist

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Quadram Institute Bioscience

The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health.

We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation.

In preparation for the full opening of the Quadram Institute in 2018, the Institute of Food Research transitioned into Quadram Institute Bioscience on April 28th 2017.

disability confident employer

Post Number1003383
Job TitlePostdoctoral Research Scientist
Closing Date11 Mar 2018
GradeSC6
Starting Salary£31,250 - £38,100
Hours per week 37
Project Title Mechanisms underpinning the gut-liver axis communication to preserve health
Expected/Ideal Start Date 01 Mar 2018
Months Duration 36
Main purpose of the job Based on the association of liver disease with disturbances in the intestinal function and the composition of the microbiome, this project will seek to define the cell-specific role of key metabolic regulators in controlling the intestinal function and how this impacts on liver physiology. Our work has a clear mechanistic and translational focus.
Department Gut Microbes and Health
Group Details Research at the Beraza Lab focuses on defining the fundamental mechanisms regulating the liver-gut interaction to preserve life-long health. We are mainly interested on understanding the role of specific metabolic regulators in modulating the gut-liver axis function. To investigate this, we use our well-established experimental models and combine molecular biology techniques with high-throughput methodologies and immune-cell characterisation procedures. Given the translational nature of our work, we collaborate with clinicians at the NNUH, as well as from our collaborators across the UK and Europe.
Advert Text Applications are invited for a Postdoctoral Research Scientist to join the Laboratory of Naiara Beraza in the Gut Health and Food Safety Programme at the Quadram Institute Bioscience (QIB).

Background:

Research at the Beraza Lab focuses on defining the fundamental mechanisms regulating the liver-gut interaction to preserve life-long health. Based on the association of liver disease with disturbances in intestinal barrier function, this project will seek to define the role of key metabolic regulators in controlling intestinal function and microbiome composition, and how this impacts on liver physiology. Our work has a strong mechanistic and translational focus.

The role:

The successful candidate will use experimental models to establish the mechanistic mediators of the intestinal-liver communication. The candidate will combine molecular biology techniques with high-throughput methodologies and immune-cell characterisation techniques to characterise the intestinal and liver mechanistic mediators to preserve metabolic homeostasis.

Given the translational nature of our work, the candidate will have the opportunity to translate the results obtained in our well-established experimental models into the clinical setting by collaborating with clinicians at the NNUH Endoscopy Unit co-housed at QI, as well as from our collaborators across the UK and Europe.

The ideal candidate:

To be considered for this post, candidates must possess a PhD in biology, biochemistry or microbiology, or equivalent. They must have knowledge of diverse molecular and cell biology methodologies, as well as data analysis skills. Previous experience of performing histological and immunohistochemical analysis of gut and liver tissue samples with light and fluorescence microscopy is also essential.

The successful applicant will be expected to work with minimal supervision and lead their own project independently; to formulate research questions, design and perform experiments, to critically process and interpret the resulting data and to design future experiments. The appointed researcher will also show capacity to work in a team, to help other members of our team and to work with internal and external collaborators. Good communication and organisational skills are also required.

The applicant will contribute to the preparation of research manuscripts and will present the lab-research data in national and international conferences. The applicant will also assist with students’ supervision.

Additional information:

Salary on appointment will be within the range £31,250 to £38,100 per annum depending on qualifications and experience. This post is for a contract of three years.

For further information and details of how to apply, please visit our web site https://jobs.quadram.ac.uk or contact the Human Resources team on 01603 450462 or nbi.recruitment@nbi.ac.uk quoting reference 1003383.

We are committed to equal opportunities and welcome applications from all sectors of society. The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values. To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

About the Quadram Institute:

The Quadram Institute is a new interdisciplinary research institute at the forefront of a new era in food and health research. It brings together clinical and non-clinical scientists in a new state-of-the-art building due for completion in 2018. It is based on the Norwich Research Park, one of the largest centres of life sciences in Europe, and home of the John Innes Centre, The Norfolk and Norwich University Hospital, The Earlham Institute and the University of East Anglia. (https://quadram.ac.uk/).

Key relationships The post holder will work together with one PhD student and occasionally with undergraduate students that visit our lab. The post holder is expected to work with other researchers from collaborating groups including the Hall and Wileman labs as well as with collaborating groups at other UK research institutions including Newcastle University.
Main Activities & ResponsibilitiesPercentage
Identify, plan, carry out and modify experiments to meet the objectives of the project40
Prepare results, reports and manuscripts for publication in leading scientific journals and other relevant media15
Disseminate research findings though presentations to various audiences at internal, national and international meetings15
Ensure research and record keeping is carried out in accordance with good practice, Scientific Integrity and in compliance with local policies and any legal requirements10
Contribute to the smooth running of the group, including the effective use of resources, supervision of visitors to the laboratory and assisting with training others, encouraging scientific excellence 10
Continually strive for excellence, seeking out and acting on feedback and relevant learning and development opportunities5
As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees.5

Education & QualificationsRequirementImportance
PhD in cell biology, biochemistry or microbiology, or equivalentEssential

Specialist Knowledge & SkillsRequirementImportance
Diverse molecular and cell biology methodologies. Essential
Experimental design, data analysis and processing. Essential
Animal handling and proven skills in a broad range of animal-related techniques. Essential
Theoretical and practical experience of in vivo modelsEssential
Performing histological and immunohistochemical analysis of gut and liver tissue samples with light and fluorescence microscopyEssential
Data analysis skillsEssential
Immune cell analysis (Flow cytometry/cell sorting)Desirable

Relevant ExperienceRequirementImportance
Experience in research related to molecular/cell biology in the gastroenterology fieldEssential
Previous experience of conducting a research project independentlyEssential
Previous experience of conducting effective literature review(s)Essential
Proven record in scientific writingEssential
Giving presentations at conferences or similar eventsDesirable
High throughput technologies, including analysis of next generation sequencing and/or metabolomics Desirable
Experience in cell culture Desirable

Interpersonal & Communication SkillsRequirementImportance
Excellent communication skills, both written and oral, including the ability to present complex information with clarity Essential
Good interpersonal skills, with the ability to work as part of a teamEssential
Able to collaborate with external groupsEssential
Enthusiastic and highly motivated to learn, develop new techniques and to train othersDesirable

Additional RequirementsRequirementImportance
Promotes equality and values diversityEssential
Ability to undertake occasional travel (national and international) related to collaborations and/or seminars Essential
Willingness to work outside standard working hours when required Desirable