Postdoctoral Scientist (Campylobacter)
Post Details
Job Title
Postdoctoral Scientist (Campylobacter)
Post Number
1003621
Closing Date
24 Feb 2019
Grade
SC6
Starting Salary
Competitive salary
Hours per week
37
Expected/Ideal Start Date
01 Apr 2019
Months Duration
23
Interview Date
11 Mar 2019

Job Description

Main Purpose of the Job

To establish MinION sequencing in Bangladesh.

Key Relationships

Work directly with computational biologists and microbiologists generating and analysing biological data for the development of the metabolic models on campylobacter. Work directly with other scientists, including PhD students, working on metabolic models for other bacteria. Work with external collaborators investigating the survival of Campylobacter jejuni in the food chain through stress survival.

Main Activities & Responsibilities

Percentage
The post holder will be expected to prepare standard operating procedures (and troubleshoot assay performance issues) for the detection of microbial DNA in clinical and environmental samples. Specifically, to develop an antibody-based capture system for the concentration of Campylobacter cells from stool and water. DNA will then be extracted and sequenced using Oxford Nanopore technology. This will be established in the UK on Campylobacter culture positive samples from the local hospital laboratory. The assay will then be transferred to the Bangladeshi partner and the successful candidate will be expected to spend time in Dhaka to support the laboratory staff in Bangladesh to establish a pipeline for Campylobacter DNA extraction and sequencing.
80
Disseminate research findings through presentations to various audiences at internal, national and international meetings
5
Collaborate with colleagues within the Institute in the development of original and world class research, including contributing to research proposals and grant applications
5
Liaise with industry and other external stakeholders
5
Ensure research and record keeping is carried out in accordance with good practice, Scientific Integrity and in compliance with local policies and any legal requirements Contribute to the smooth running of the group, including the effective use of resources, supervision of visitors to the laboratory and assisting with training others, encouraging scientific excellence
5
Continually strive for excellence, seeking out and acting on feedback and relevant learning and development opportunities
As agreed with the line manager, any other duties commensurate with the nature of the post

Person Profile

Education & Qualifications

Requirement
Importance
PhD in a biological subject including analysis of next generation sequence data
Essential

Specialist Knowledge & Skills

Requirement
Importance
Understanding of genomic analysis from diarrhoeal pathogens
Essential
Knowledge of the genetics of antibacterial resistance in Gram negative bacteria
Essential
Knowledge of quality control procedures in a suitable clinical/manufacturing environment
Essential
Ability to analyse next generation sequence data for bacterial identification
Essential

Relevant Experience

Requirement
Importance
Previous experience of working in academic and service delivery environments
Essential
Experience of culture based identification methods for bacteria
Desirable

Interpersonal & Communication Skills

Requirement
Importance
Excellent communication skills, both written and oral, including the ability to present complex information with clarity
Essential
Demonstrated ability to work independently, using initiative and applying problem solving skills
Essential
Excellent time management and organisational skills
Essential
Ability to collaborate with internal and external stakeholders
Essential
Promotes and strives for continuous improvement
Essential
Good interpersonal skills, with the ability to work as part of a team
Essential

Additional Requirements

Requirement
Importance
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work
Essential
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
Essential
Willingness to work outside standard working hours when required
Essential
Ability to undertake occasional travel (national and international) related to collaborations and/or seminars
Essential
Attention to detail
Essential
Promotes equality and values diversity
Essential
A working knowledge of arabic
Desirable

Who We Are

Quadram Institute Bioscience

The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health.

We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation.

Department

Microbes in the Food Chain

Group Details

Professor John Wain works in public health microbiology; in particular the development of tools for molecular epidemiology and bacterial identification. The group’s research will be based at Quadram Institute Bioscience and is also linked with the Norwich Medical School of the University of East Anglia. The
overarching aim of the research program is to improve clinical diagnosis of infectious disease through the development of new techniques for understanding bacterial strain variation. The group includes biologists as well as bioinformaticians and is now expanding, through collaboration with Oxford-Brookes into metabolic modelling.

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Applications are invited for a Postdoctoral Scientist to join the Laboratory of Professor John Wain at the Quadram Institute Bioscience (QIB), based in Norwich, UK.

The Wain Group:

Professor John Wain works in public health microbiology; in particular the development of tools for molecular epidemiology and bacterial identification. The group’s research is based at Quadram Institute Bioscience and is also linked with the Norwich Medical School of the University of East Anglia. The overarching aim of the research program is to improve clinical diagnosis of infectious disease through the development of new techniques for understanding bacterial strain variation. The group includes biologists as well as bioinformaticians and is now expanding, through collaboration with Oxford-Brookes University into metabolic modelling.

The role:

The post holder will be expected to prepare standard operating procedures (and troubleshoot assay performance issues) for the detection of microbial DNA in clinical and environmental samples. Specifically, to develop an antibody-based capture system for the concentration of Campylobacter cells from stool and water. DNA will then be extracted and sequenced using Oxford Nanopore technology. This will be established in the UK on Campylobacter culture positive samples from the local hospital laboratory. The assay will then be transferred to the Bangladeshi partner and the successful candidate will be expected to spend time in Dhaka to support the laboratory staff in Bangladesh to establish a pipeline for Campylobacter DNA extraction and sequencing.

The ideal candidate:

Candidates should possess a PhD in a biological subject including analysis of next generation sequence data. An understanding of genomic analysis from diarrhoeal pathogens is essential, as is knowledge of the genetics of antibacterial resistance in Gram negative bacteria. Experience of culture-based identification methods for bacteria would be advantageous.

Additional information:

Salary on appointment will be within the range £31,250 to £38,100 per annum depending on qualifications and experience. This post is for a contract of 23 months.

For further information and details of how to apply, please visit our web site https://jobs.quadram.ac.uk or contact the Human Resources team on 01603 450462 or nbi.recruitment@nbi.ac.uk quoting reference 1003621.

We are committed to equal opportunities and welcome applications from all sectors of society. The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values. To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

About the Quadram Institute:

The Quadram Institute is a new interdisciplinary research institute at the forefront of a new era in food and health research. Its mission is to understand how food and the gut microbiota are linked to the promotion of health and the prevention of disease. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital and BBSRC, it brings together scientists and clinicians in a new state-of-the-art building. The Quadram Institute is based on the Norwich Research Park, one of Europe’s largest centres of life sciences and home of the John Innes Centre and The Earlham Institute.