Research Assistant (Microbiology)
Post Details
Job Title
Research Assistant (Microbiology)
Post Number
1003675
Closing Date
23 Apr 2019
Grade
SC7
Starting Salary
£24,300 - £29,750
Hours per week
37
Project Title
GI Microbiome and infection diagnosis
Expected/Ideal Start Date
29 Apr 2019
Months Duration
12

Job Description

Main Purpose of the Job

An exciting opportunity is available for a Research Assistant to join the Laboratory of Professor Arjan Narbad in the Gut Microbes and Health Programme at Quadram Institute Bioscience (QIB), based in Norwich, UK.

Gastrointestinal illness continues to be a considerable cause of morbidity in the UK and recent estimates are of up to 17 million sporadic, community cases of IID and 1 million GP consultations annually. Current diagnostic strategies do not detect an aetiological agent in the majority of cases. Recent advances in next generation sequencing technologies provides a unique opportunity to assay the microbiome in an untargeted manner allowing us to explore GI diseases with unknown etiology.

The main purpose of the post is to evaluate the use of metagenomic and metabolomic profiles of faecal specimens collected from patients with diarrhoea for detection of pathogens and identification of biomarkers of disease.

We are seeking a microbiologist/molecular biologist to join a team investigating the relationship between gut bacteria and gastrointestinal infections.You will hold a degree or equivalent qualification in Microbiology or Molecular Biology and have the experience and motivation to work on complex microbial communities. You will have experience of handling anaerobic bacteria and be willing to work with clinical samples.

Key Relationships

The post holder will be responsible for experimental research under the supervision of Line Manager Prof. Arjan Narbad. The post holder will work in close collaboration with one postdoctoral researcher and a PhD student working on this NIHR funded project. They will also interact with Professor Jim McClauchlin at PHE in Colindale

Main Activities & Responsibilities

Percentage
Co-ordination of sample collection and extraction of bacterial Genomic DNA
40
Isolation and identification of bacteria
20
Undertake additional lab duties and management of couture stocks
20
Preparation of samples for metabolomics analysis
10
Written communication of results and preparation of data for publications
5
As agreed with the line manager, any other duties commensurate with the nature of the post
5

Person Profile

Education & Qualifications

Requirement
Importance
Degree in Microbiology or Biological Sciences
Essential

Specialist Knowledge & Skills

Requirement
Importance
Experience of working in a microbiology laboratory environment
Essential

Relevant Experience

Requirement
Importance
Ability to handle pathogens safely
Desirable
Experience of molecular profiling of microbial communities
Desirable

Interpersonal & Communication Skills

Requirement
Importance
Able to work effectively as part of a team
Essential
Excellent communication skills, both written and oral
Essential
Excellent time management and organisational skills
Essential
Ability to follow instructions/standard operating procedures
Essential
Good interpersonal skills, with the ability to work well as part of a team
Desirable

Additional Requirements

Requirement
Importance
Promotes equality and values diversity
Essential
Willingness to embrace the expected values and behaviours of the Institute, ensuring it is a great place to work
Essential
Ability to work independently
Essential
Ability to maintain confidentiality and security of information where appropriate
Essential
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
Essential
Willingness to work outside standard working hours when required
Essential
Attention to detail
Essential

Who We Are

Quadram Institute Bioscience

The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health.

We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation.

For more information about working at Quadram Institute Bioscience, please click here.

Department

Food Innovation and Health

Group Details

The Narbad group is working on the role of gut commensals on health and disease in humans and animals. We have particular interest in isolation and characterisation of gut commensal bacteria of animal and human origin for use as probiotics for the exclusion of gut pathogens. Mechanisms of competitive exclusion phenomena are being investigated with the objective of designing strains with improved functionality. Identification and characterisation of novel antimicrobials including bacteriophage endolysins and bacteriotherapy that target gut pathogens such as Clostridium difficile and the impact of these interventions on the gut microbial communities is another area of active research within the group.

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Research Assistant (Microbiology)

An exciting opportunity is available for a Research Assistant to join the Laboratory of Professor Arjan Narbad in the Gut Microbes and Health Programme at Quadram Institute Bioscience (QIB), based in Norwich, UK.

Background:

The Narbad group is working on the role of gut commensals on health and disease in humans and animals. We have particular interest in isolation and characterisation of gut commensal bacteria of animal and human origin for use as probiotics for the exclusion of gut pathogens.

Mechanisms of competitive exclusion phenomena are being investigated with the objective of designing strains with improved functionality. Identification and characterisation of novel antimicrobials including bacteriophage endolysins and bacteriotherapy that target gut pathogens such as Clostridium difficile and the impact of these interventions on the gut microbial communities is another area of active research within the group.

The role:

We are seeking a graduate microbiologist/biologist to join a team investigating the relationship between gut bacteria and gastrointestinal infections. The main purpose of this post is to evaluate the use of metagenomics for detection of pathogens and identification of biomarkers of disease. The post holder will collect clinical samples and contribute to extensive analysis of gut microbiome and the assessment of the metabolic biomarkers using metabolomics platforms.

The ideal candidate:

The successful candidate will hold a degree or equivalent qualification in Microbiology or biological sciences. The post holder will have experience of working in a microbiology laboratory environment and be willing to learn to handle pathogenic bacteria and molecular profiling methods.

Additional information:

Salary on appointment will be within the range £24,300 to £29,750 per annum depending on qualifications and experience. This is a full time post for a contract of 12 months.

Please note, this position does not meet UKVI requirements to sponsor a Tier 2 visa.

We are committed to equal opportunities and welcome applications from all sectors of society. The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values. To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

About the Quadram Institute:

The Quadram Institute is a new interdisciplinary research institute at the forefront of a new era in food and health research. Its mission is to understand how food and the gut microbiota are linked to the promotion of health and the prevention of disease. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital and BBSRC, it brings together scientists and clinicians in a new state-of-the-art building. The Quadram Institute is based on the Norwich Research Park, one of Europe’s largest centres of life sciences and home of the John Innes Centre and The Earlham Institute. (https://quadram.ac.uk/).

The closing date for applications will be 23 April 2019.

The Quadram Institute Bioscience is a registered charity (No. 1058499) and is an Equal Opportunities Employer.