Research Scientist (Clinical Metagenomics)
Post Details
Job Title
Research Scientist (Clinical Metagenomics)
Post Number
Closing Date
24 Jul 2019
Starting Salary
£31,250 - £38,100
Hours per week
Project Title
Development of key technologies for real-time diagnosis, surveillance and intervention of resistant-bacterial infections based on nanopore sequencing.
Expected/Ideal Start Date
02 Sep 2019
Months Duration
Interview Date
02 Aug 2019

Job Description

Main Purpose of the Job

To optimise, transfer and implement a clinical metagenomics test for the diagnosis of lower respiratory tract infection.

Key Relationships

The post holder will work closely with a UK SME (Oppilotech), a Chinese diagnostics company (Simcere) and Chinese hospitals in Beijing.

Main Activities & Responsibilities

This project will involve further development and implementation of a nanopore clinical metagenomics pipeline developed in the O'Grady group (recently published in Nature Biotechnology) for the rapid diagnosis of lower respiratory tract infection.
As agreed with line manager, any other duties commensurate with the nature of the role

Person Profile

Education & Qualifications

PhD in biological sciences or equivalent

Specialist Knowledge & Skills

Genomics or metagenomics
Molecular biology
Infectious diseases diagnostics
Sample preparation
Microbiological culture

Relevant Experience

Experience of scientific collaboration and supervision
A publication track record appropriate for career stage
Experience using nanopore sequencing
Experience running research projects
Experience with respiratory samples

Interpersonal & Communication Skills

Ability to cooperate to reach a common goal
Strong communication skills, both written and verbal
The ability to make decisions and take responsibility
The ability to manage deadlines even under stressful situations
Good interpersonal skills, with the ability to work well as part of a team

Additional Requirements

Promotes equality and values diversity
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
Willingness to work outside standard working hours when required
Attention to detail

Who We Are

Quadram Institute Bioscience

The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health.

We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation.

For more information about working at Quadram Institute Bioscience, please click here.


Microbes in the Food Chain

Group Details

The O'Grady lab is part of the Microbial Metagenomics Research Laboratory (MMRL), which focusses on translating metagenomics technologies for investigating human pathogens in different sample types.


Advert Text

Research Scientist (Nanopore sequencing based Clinical Metagenomics)

Applications are invited for a Research Scientist to join the Laboratory of Dr Justin O’Grady in the Microbes in the Food Chain Programme at Quadram Institute Bioscience (QIB), based in Norwich, UK.

The role:

The O’Grady group is looking to recruit a Research Scientist on a prestigious Innovate UK UK-China AMR grant titled "Development of key technologies for real-time diagnosis, surveillance and intervention of resistant-bacterial infections based on nanopore sequencing". This is a 3 year post where the successful candidate will further develop and implement clinical metagenomics technology developed in the O'Grady group (published in Nature Biotechnology, June 2019) for the rapid diagnosis of lower respiratory tract infection . The post holder will work closely with a UK SME (Oppilotech), a Chinese diagnostics company (Simcere) and Chinese hospitals in Beijing. The job will involve metagenomics method optimisation, technology transfer, analytical and clinical validation and a co-ordination of a diagnostics trial. There will be the opportunity for travel to China (Beijing/Nanjing/Shanghai) 2-3 times per year for up to two weeks (candidates who speak Mandarin are very welcome to apply). There will also be the opportunity for the Research Scientist to develop their own relevant research interests and we actively encourage staff to apply for fellowships and grants to further their career.

The ideal candidate:

The Research Scientist should have a PhD in biological sciences or equivalent. They will have a background in genomics, metagenomics and/or molecular biology and will have an interest in clinical infectious diseases. Relevant skills in data analysis, diagnostics and running research projects are an advantage. The ideal candidate will also have a publication track record appropriate for their career stage, and experience of scientific collaboration and supervision.

Additional information:

Salary on appointment will be within the range £31,250 to £38,100 per annum depending on qualifications and experience. This post is for a contract of 3 years.

Interviews will be held on 2 Aug 2019.

We are committed to equal opportunities and welcome applications from all sectors of society. The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values. To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

About the Quadram Institute:

The Quadram Institute is a new interdisciplinary research institute at the forefront of a new era in food and health research. Its mission is to understand how food and the gut microbiota are linked to the promotion of health and the prevention of disease. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital and BBSRC, it brings together scientists and clinicians in a new state-of-the-art building. The Quadram Institute is based on the Norwich Research Park, one of Europe’s largest centres of life sciences and home of the John Innes Centre and The Earlham Institute. (

The closing date for applications will be 24 July 2019.

The Quadram Institute Bioscience is a registered charity (No. 1058499) and is an Equal Opportunities Employer.