- Job Title
- Project Scientist
- Post Number
- Closing Date
- 24 Feb 2019
- Starting Salary
- £24,300 - £29,750
- Hours per week
- Project Title
- Role of early life gut microbiota in colonisation resistance development
- Expected/Ideal Start Date
- 25 Mar 2019
- Months Duration
Main Purpose of the Job
This post will provide an exciting opportunity for a motivated individual to join a dynamic, multi-disciplinary research team investigating the early life microbiota and host interactions.
The goal of the position is to support ongoing lab activities including microbiota studies (clinical and lab-based) and support new projects to identify ‘healthy’ early life microbiota signatures.
Liaise with group members and external collaborators and coordinate projects
Main Activities & Responsibilities
- Microbiological studies (culturing, PCR, molecular manipulation etc.)
- Immune and metabolites studies, from clinical and pre-clinical samples
- Liaise and perform lab work with/for group members and external collaborators
- Lab management activities (ordering etc.)
- Train students and visitors to the lab
- Clinical and Pre-clinical microbiota studies (sample collection/organisation, database management, DNA extraction, amplicon generation, NGS preparation etc.)
- As agreed with line manager, any other duties commensurate with the nature of the post
Education & Qualifications
- BSc or equivalent in biomedical science or related field
Specialist Knowledge & Skills
- Microbiology skills and experience (culturing, phenotypic analysis)
- An understanding of biological research methods
- Experience of working in biomedical laboratory/industry based research
- Experience with microbiota studies including experience/knowledge of NGS
- Experience with host response analysis
Interpersonal & Communication Skills
- Ability to work under time pressure and to tight deadlines
- A desire to learn, to innovate and to move out of their comfort zone
- Good organisational and time management skills
- Good interpersonal skills, with the ability to work as part of an active research team
- Demonstrated ability to work independently, using initiative and applying problem solving skills
- Excellent communication skills, both written and oral, including the ability to present complex information with clarity
- Promotes and strives for continuous improvement
- Ability to communicate with collaborators across a broad range of fields
- Promotes equality and values diversity
- Ability to maintain confidentiality and security of information where appropriate
- Attention to detail
- Willingness to undertake any necessary training for the role
Who We Are
Quadram Institute Bioscience
The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health.
We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation.
Gut Microbes and Health
The Hall Lab’s research focus involves defining the complex interactions of the intestinal microbiota, particularly during the early life developmental window. The group is focused on how microbial communities and specific microbiota members (e.g. Bifidobacterium) interact with other microbes and the host including: (i) the impact of diet, (ii) how these microbes modulate critical infection (i.e. colonisation) resistance, and (iii) beneficially impact host responses, including immune regulation. Another key goal is to identify bifidobacterial communities and their components that can restore a disturbed early life microbiota back into one able to promote health. We utilise multi-disciplinary approaches to answer these key questions including; microbiology (in vitro model-colon chemostat systems for complex culturing, molecular microbiology), metabolomics (NMR, MS), next generation sequencing (RNASeq, 16S rRNA, WGS, both host and microbe), bioinformatics tools, in vivo models (germ-free and infection models) and human studies (preterm/term infants and adults).
Applications are invited for a Project Scientist to join the Laboratory of Lindsay Hall in the Gut Microbes and Health Programme at the Quadram Institute Bioscience (QIB).
The Hall lab’s research focus involves defining the interactions of the host with the gut microbiota, with a particular focus on the early life developmental window, and the genus Bifidobacterium. The lab has three main research themes including, microbe-diet interactions, microbe-host cross-talk, and colonisation resistance. For more details please visit www.halllab.co.uk
The lab utilises multi-disciplinary approaches to explore these themes including; microbiology (model-colon chemostat systems, molecular microbiology), metabolomics (NMR, MS), next generation sequencing (RNASeq, 16S rRNA, WGS, both host and microbe), bioinformatics tools, in vivo models (germ-free and infection models), and human studies (preterm/term infants).
The goal of this Wellcome Trust funded position is to support ongoing lab activities including microbiota studies (clinical and lab-based) and support new projects to identify ‘healthy’ early life microbiota signatures.
Specific duties of the role will include sample collection/organisation, DNA extraction, sequencing preparation, culturing, and in vitro experiments. The post holder will assist with laboratory management activities, such as ordering, and train students and visitors to the laboratory.
The ideal candidate:
Applicants should have a background in biological research (e.g. microbiology), and ideally microbiota studies, and will act as a key member of the research group. A BSc or equivalent in biomedical science, or a related field is essential, as is outstanding personal initiative and communication skills.
Salary on appointment will be within the range £24,300 to £29,750 per annum depending on qualifications and experience. This post is a fulltime post for a period of 10 months.
Please note this post does not meet the UKVI requirements to provide tier 2 visa sponsorship.
We are committed to equal opportunities and welcome applications from all sectors of society. The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values. To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work.
As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.
About the Quadram Institute:
The Quadram Institute is a new interdisciplinary research institute at the forefront of a new era in food and health research. Its mission is to understand how food and the gut microbiota are linked to the promotion of health and the prevention of disease. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital and BBSRC, it brings together scientists and clinicians in a new state-of-the-art building. The Quadram Institute is based on the Norwich Research Park, one of Europe’s largest centres of life sciences and home of the John Innes Centre and The Earlham Institute. (https://quadram.ac.uk/).