Research Scientist
Post Details
Job Title
Research Scientist
Post Number
1004118
Closing Date
31 Oct 2021
Grade
SC6
Starting Salary
£32,578 - £39,938
Hours per week
37
Project Title
Copper-induced microbiota shifts and its effect on pig-gut colonisation by sil and sopE encoding Salmonella
Expected/Ideal Start Date
01 Feb 2022
Months Duration
36
Interview Date
30 Nov 2021

Job Description

Main Purpose of the Job

Applications are invited for a Research Scientist to join the Laboratory of Prof Rob Kingsley in the Microbes in the Food Chain programme at Quadram Institute Bioscience (QIB), based in Norwich, UK. The successful candidate will be a key scientist on a collaborative project that will determine changes in the microbiome of the pig gut in response to Copper supplementation of feed, isolate and taxonomic identification of pig gut microbiota, and investigate the interaction of gut microbiota with Salmonella. The post will be partly laboratory based and expertise in microbiology is essential. Experience of working with large datasets is desirable and training in an in vitro pig gut model and the foundations of bioinformatics are available as required. The post holder will work alongside bioinformaticians with expertise in metagenome sequence analysis at the Quadram Institute, and coordinate an on-farm study and a large animal infection model with external collaborators.

Key Relationships

Line management and mentorship will be provided by Prof Rob Kingsley and Dr Falk Hildebrand and they will be the main day-to-day contacts. The post holder will coordinate the collaboration with Prof Roberto La Ragione (University of Surrey), Prof Mark Stevens (Roslin Institute), Prof Trevor Lawley (Sanger Institute) and Sparsholt Farm (Hampshire). Opportunities for visits for training or experimental purposes are available including extended periods of secondment as required. The post holder will also interact with Postdoctoral, postgraduate and technical staff within the Kingsley and Hildebrand groups for training or knowledge exchange. The Quadram Institute also has an excellent core bioinformatics group for specific training or assistance.

Main Activities & Responsibilities

Percentage
Identify, plan, carry out and modify laboratory experiments to meet the objectives of the project
55
Computational analysis
15
Prepare results, reports and manuscripts for publication in leading scientific journals and other relevant media
10
Co-supervision of junior lab members
10
Ensure research and record keeping is carried out in accordance with good practice, Scientific Integrity and in compliance with local policies and any legal requirements
5
Continually strive for excellence, seeking out and acting on feedback and relevant learning and development opportunities
5
As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees.

Person Profile

Education & Qualifications

Requirement
Importance
PhD in Microbiology or related discipline
Essential

Specialist Knowledge & Skills

Requirement
Importance
Expertise in Microbiology
Essential
Scientific writing skills
Essential
Demonstrated skills in and knowledge Anaerobic microbiology
Desirable
Skills and knowledge in Molecular biology
Desirable
Demonstrated skills using R or similar
Desirable
Skills in bioinformatic analysis
Desirable
Knowledge of gut microbiota
Desirable
Knowledge of bacterial pathogens
Desirable

Relevant Experience

Requirement
Importance
Proven record in scientific writing
Essential
Experience of oral research presentations
Essential
Preparing data / information for grant proposals
Desirable
Experience of supervising, training and mentoring visitors and students
Desirable
Experience of metagenomics
Desirable
Working with microbiota - culture / analysis
Desirable
Experience of working with large datasets
Desirable

Interpersonal & Communication Skills

Requirement
Importance
Excellent communication skills, both written and oral, including the ability to present complex information with clarity and oral presentation skills
Essential
Good interpersonal skills, with the ability to work as part of a team
Essential
Demonstrated ability to work independently, using initiative and applying problem solving skills
Essential
Excellent time management and organisational skills
Essential
Ability to collaborate with internal and external stakeholders
Essential
Ability to follow instructions/Standard Operating Procedures
Essential
Promotes and strives for continuous improvement
Essential
Collaborative research skills
Desirable

Additional Requirements

Requirement
Importance
Publication record commensurate with level of experience
Essential
Attention to detail
Essential
Promotes equality and values diversity
Essential
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work
Essential
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
Essential
Ability to maintain confidentiality and security of information where appropriate
Essential
Willingness to work outside standard working hours when required
Essential
Ability to undertake occasional travel (national and international) related to collaborations and/or seminars
Essential

Who We Are

Quadram Institute Bioscience

The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health.

We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation.

The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on +44 (0)1603 450888 or nbi.recruitment@nbi.ac.uk.

For more information about working at Quadram Institute Bioscience, please click here.

Department

Microbes in the Food Chain

Group Details

The Kingsley group combines bioinformatics, genomics, molecular microbiology and models of infection to investigate the evolution of interactions between pathogens, the environment and the host. We investigate the genomic diversity of bacterial pathogens and their associated microbial communities. We aim to understand the function and evolutionary history of genes important to disease, transmission, drug resistance and phage sensitivity. We test hypotheses using classical molecular genetics, microbiology and models of infection. Our work has shed light on how new pathogens emerge and evolve in response to farming practice, and how this may affect productivity, animal welfare and risk to food safety.

Living in Norfolk

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Research Scientist

Applications are invited for a Research Scientist to join the Laboratory of Prof Rob Kingsley in the Microbes in the Food Chain programme at Quadram Institute Bioscience (QIB), based in Norwich, UK.

Background:

The Kingsley group combines bioinformatics, genomics, molecular microbiology and models of infection to investigate the evolution of interactions between pathogens, the environment and the host. We investigate the genomic diversity of bacterial pathogens and their associated microbial communities. We aim to understand the function and evolutionary history of genes important to disease, transmission, drug resistance and phage sensitivity. We test hypotheses using classical molecular genetics, microbiology and models of infection. Our work has shed light on how new pathogens emerge and evolve in response to farming practice, and how this may affect productivity, animal welfare and risk to food safety.

The role:

A three-year Research Scientist position is available to explore the link between the disruption of the pig gut microbiota by copper in pig feed and the global emergence of a new, clinically highly relevant, variant of Salmonella. Copper is widely used in the pig farming industry as a growth promotor, but because it is toxic to bacteria it also disrupts the microbiota that provides colonisation resistance to pathogenic bacteria, such as Salmonella. The post holder be the key scientist in a collaborative project that will unravel the interactions between Salmonella and the pig gut microbiota to understand if copper mediated disruption of gut affects colonisation by this important food borne pathogen.

The ideal candidate:

The ideal candidate will have a PhD in  Microbiology or related discipline. The post suits an ambitious laboratory scientist with a strong background in Microbiology. The ideal candidate will also have skills in scientific writing and experience of oral research presentations. Experience of working with large datasets is desirable.

Additional information:

Salary on appointment will be within the range £32,578 to £39,398 per annum depending on qualifications and experience. This is a full-time for a contract of 3 years.

For informal enquiries please contact Prof Rob Kingsley (rob.kingsley@quadram.ac.uk)

Interviews will be held on 30th November 2021.

We are committed to equal opportunities and welcome applications from all sectors of society.  The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values.  To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

International applications are welcome.

About the Quadram Institute:

The Quadram Institute is a new interdisciplinary research institute dedicated to understanding how food and microbes interact to promote health and prevent disease. Its mission is to deliver healthier lives through innovation in gut health, microbiology and food. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital and BBSRC, it brings together scientists and clinicians in a state-of-the-art building on the Norwich Research Park. This is one of Europe’s largest centres of life sciences and home of the John Innes Centre and The Earlham Institute. (https://quadram.ac.uk/).

The closing date for applications will be 31st October 2021

The Quadram Institute Bioscience is a registered charity (No. 1058499) and is an Equal Opportunities Employer.