Research Scientist
Post Details
Job Title
Research Scientist
Post Number
1004305
Closing Date
18 Aug 2022
Grade
SC6
Starting Salary
£33,050 - £40,750
Hours per week
37
Project Title
Bacteriophage for Gut Health
Expected/Ideal Start Date
01 Nov 2022
Months Duration
36

Job Description

Main Purpose of the Job

The post holder will be working on a three-year BBSRC-funded project on Bacteriophages for Gut Health, a collaboration with the Juge lab and Hall lab at the Quadram Institute Bioscience. The project aims to investigate the interaction between naturally occurring intestinal bacteriophage communities and the cells in the human gastrointestinal tract, using high-throughput sequencing and advanced organoid models available at QIB.

As the core Research Scientist on the project, the post holder will contribute to the delivery of all work packages of the grant, including the investigation of faecal phage communities from infants and adults using metagenomics, their application to organoids, exploring cellular responses and synthesising the results for future applications in phage therapy. The post holder will be involved in viromics, phage culturing, organoid model experiments and biomarker assessments, and will liaise with other Research Scientists on the project to share expertise, perform experiments together and to deliver project milestones. The post holder will be supported by dedicated core bioinformatics staff for viromics/metagenomics analyses.

Furthermore, the post holder will help organise and attend project meetings and contribute to communication and dissemination of results, including presentation of findings at scientific conferences and the publication of papers. The post holder will be given the opportunity to enrol in training courses related to bioinformatics and career development, and will assist in the daily supervision of undergraduate and/or postgraduate students at QIB.

Key Relationships

The post holder will work with other group members at the Adriaenssens group as well as other members of the Quadram Institute Bioscience. The post holder is expected to develop and maintain strong working relationships with all partners in the grant, specifically Research Scientists from the Juge group working with organoids and the Hall group, as well as core support Bioinformaticians and external project collaborator Krystyna Dabrowska at the Hirzfeld Institute, Poland.

Main Activities & Responsibilities

Percentage
Bioinformatic analysis of virome/phageome/metagenome sequence data
35
Assist in organoid culturing and sourcing of materials and perform phage-organoid experiments
20
Phage and bacteria culturing, phage community virion isolation and nucleic acid extraction
20
Dissemination of results through publication of scientific papers, media posts, and attending scientific conferences
15
Assist with supervising students and visiting workers in the group
5
As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees.
5

Person Profile

Education & Qualifications

Requirement
Importance
PhD in Microbiology, Biotechnology, Bioscience Engineering or a related Life Science subject
Essential

Specialist Knowledge & Skills

Requirement
Importance
Excellent laboratory and experimental design skills
Essential
Microbiology techniques related to phage and/or bacteria culturing
Essential
Proven record of publications appropriate with experience
Essential
Bioinformatics skills related to viromics data analysis or a keen interest to develop these skills
Essential

Relevant Experience

Requirement
Importance
Laboratory experience in microbiology
Essential
Experience in working with bacteriophages
Desirable
Experience in working with human tissue
Desirable
Experience with bioinformatics processing of metagenomics data
Desirable
Previous experience in viromics or metagenomics
Desirable

Interpersonal & Communication Skills

Requirement
Importance
Good interpersonal skills, with the ability to work well as part of a team
Essential
Good communication skills, both written and verbal
Essential
Ability to work to deadlines
Essential
Ability to work and manage projects independently
Essential
Ability to communicate science clearly with collaborators and a general audience
Essential

Additional Requirements

Requirement
Importance
Attention to detail
Essential
Promotes equality and values diversity
Essential
Observe best practices in data management and research integrity
Essential
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work
Essential
Willingness to work outside standard working hours when required
Essential
Willingness to supervise students
Essential
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
Essential

Who We Are

Quadram Institute Bioscience

The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health.

We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation.

The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on +44 (0)1603 450888 or nbi.recruitment@nbi.ac.uk.

For more information about working at Quadram Institute Bioscience, please click here.

Department

Gut Microbes and Health

Group Details

The Adriaenssens group is a vibrant and collaborative research group looking into all things phage. We use culture-dependent and independent approaches to understand the role of bacteriophages as part of the human gut microbiome working both with single phage-host pairs and complex microbial communities. We have a strong interest in the use of bacteriophages as biocontrol agents.

Living in Norfolk

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Research Scientist

Applications are invited for a Research Scientist to join the Laboratory of Dr Evelien Adriaenssens in the Gut Microbes and Health Programme at Quadram Institute Bioscience (QIB), based in Norwich, UK.

Background:

The Adriaenssens group is a vibrant and collaborative research group looking into all things phage. We use culture-dependent and independent approaches to understand the role of bacteriophages as part of the human gut microbiome working both with single phage-host pairs and complex microbial communities. We have a strong interest in the use of bacteriophages as biocontrol agents.

The role:

As the Research Scientist on the BBSRC-funded project “Bacteriophages for Gut Health”, the post holder will contribute to the delivery of all work packages of the grant, including the investigation of faecal phage communities from infants and adults using metagenomics, their application to organoids, exploring cellular responses and synthesising the results for future applications in phage therapy. The post holder will be involved in viromics, phage culturing, organoid model experiments and biomarker assessments, and will liaise with other Research Scientists on the project to share expertise, perform experiments together and to deliver project milestones. Key relationships will be developed with members of the Juge and Hall Groups at QIB, co-investigators on the project.

The Research Scientist will help organise and attend project meetings and contribute to communication and dissemination of results, including presentation of findings at scientific conferences and the publication of papers. The post holder will be given the opportunity to enrol in training courses related to bioinformatics, with career development and will assist in the daily supervision of undergraduate and/or postgraduate students at QIB.

The ideal candidate:

The ideal candidate will hold a PhD in Microbiology, Biotechnology, Bioscience Engineering or a related Life Science subject, and will be passionate about Bacteriophages and investigating their role in the gut microbiome.

The responsibilities are split between laboratory work in phage biology, viromics, organoid experimentation and dry lab work in bioinformatics, meaning we are looking for a flexible individual willing to learn a wide range of techniques. Previous experience in viromics or metagenomics is desirable. Applicants with limited experience in human tissue culturing or bioinformatics will be considered, as these experiments are collaborative with other Research Scientists on the project. Good communications skills and the ability to coordinate with team members to deliver objectives are essential. 

Additional information:

Salary on appointment will be within the range £33,050 to £40,750 per annum depending on qualifications and experience. This is a full-time post for a contract of 3 years. The successful applicant will be available to start from the 1st of November 2022.

We are committed to equal opportunities and welcome applications from all sectors of society.  The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values.  To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

About the Quadram Institute:

The Quadram Institute is a new interdisciplinary research institute dedicated to understanding how food and microbes interact to promote health and prevent disease. Its mission is to deliver healthier lives through innovation in gut health, microbiology and food. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital and BBSRC, it brings together scientists and clinicians in a state-of-the-art building on the Norwich Research Park. This is one of Europe’s largest centres of life sciences and home of the John Innes Centre and The Earlham Institute. (https://quadram.ac.uk/).

The closing date for applications will be 18th August 2022.

The Quadram Institute Bioscience is a registered charity (No. 1058499) and is an Equal Opportunities Employer.