Microbiome Technician
Post Details
Job Title
Microbiome Technician
Post Number
1004610
Closing Date
22 Feb 2024
Grade
SC7
Starting Salary
£27,750 - £34,500
Hours per week
37
Project Title
Microbiome technician working with human samples
Months Duration
6

Job Description

Main Purpose of the Job

Applications are invited for a Microbiome technician to join the Laboratory of Dr Hildebrand in the Gut Microbes and Health programme at Quadram Institute Bioscience (QIB), based in Norwich, UK.

How do gut bacteria colonize new human hosts and persist for decades with the same human? And how many fungi are present in human microbiomes? To answer these and follow up questions, the Hildebrand group received an ERC Starter grant that the post holder will work on in this project.

Our aim is to dissect these questions on a family centric cohort, PEARL-AGE (https://quadram.ac.uk/pearl-agestudy/).
We’re looking for an enthusiastic researcher interested in working with human samples, DNA extractions and sequencing library preparations (ilumina, PacBio, potentially ONT). In addition the candidate will also be involved in ongoing research within the group, such as biasing DNA extractions to improve overall throughput of current lab protocols as well as looking into mechanisms to reduce overall costs for these.

Long-term, this work will contribute to developing the next generation of human gut microbiome treatments and enabling personalised & data driven medicine.

Key Relationships

The post holder will work closely with other group members, the line manager Dr Falk Hildebrand (Group Leader), group members, and key collaborators (e.g. Drs Chris Quince, Laura Lehtovirta-Morley, Richard Leggett). The applicant is expected to participate in group meetings and help members of the Hildebrand group in their daily tasks. The applicant will have direct access to established PacBio/ONT, Hi-C and single cell sequencing facilities, as well as one of UK’s largest HPC cluster at the NRP.

Main Activities & Responsibilities

Percentage
Work with human stool samples to extract DNA at high quality and prepare for sequencing with various technologies
30
Enrich fuNgi from human stool
30
Assist in recruitment and processing samples in currently ongoing studies in the Hildebrand group
20
Assist with various wetlab techniques as required for Hildebrand group projects
10
As agreed with line manager, any other duties commensurate with the nature of the role
10

Person Profile

Education & Qualifications

Requirement
Importance
MRes in Biology or similar subject (or ongoing MRes)
Essential

Specialist Knowledge & Skills

Requirement
Importance
Basic wetlab techniques
Essential
Fungal enrichments
Essential
DNA extractions
Essential
PacBio Library preps
Essential

Relevant Experience

Requirement
Importance
R programming
Essential
Experience of working in a research environment
Essential
Microbial wetlab techniques
Essential

Interpersonal & Communication Skills

Requirement
Importance
Ability to follow instructions/Standard Operating Procedures
Essential
Demonstrated ability to work independently, using initiative and applying problem solving skills
Essential
Good communication skills, both written and verbal
Essential
Good interpersonal skills, with the ability to work well as part of a team
Essential

Additional Requirements

Requirement
Importance
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
Essential
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work
Essential
Willingness to work outside standard working hours when required
Essential
Attention to detail
Essential
Promotes equality and values diversity
Essential

Who We Are

Quadram Institute Bioscience

The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health.

We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation.

The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on +44 (0)1603 450888 or nbi.recruitment@nbi.ac.uk.

For more information about working at Quadram Institute Bioscience, please click here.

Department

Food, Microbiome and Health

Group Details

The Hildebrand group uses metagenomics to research the diversity, community interactions, and evolution of microbes in communities. Currently the group has projects in both human associated and environmental (soil, lakes) microbiomes, for which custom bioinformatic solutions are developed in-house to enable a wholistic microbiome exploration. With this, we can go beyond species-centric interpretations of microbial ecosystems, to understand the system as a whole based on specific differences in its members. For representative publications relevant to the post please see (doi: 10.1016/j.chom.2021.05.008, doi: 10.1128/mSystems.00881-21, https://scholar.google.com/citations?user=VTfzjTgAAAAJ ) and www.falk.science for group information.

The Quadram Institute is based on the Norwich Research Park, which is one of the largest single-site concentrations of research in food, genomics, and health in Europe. The Park hosts four independent internationally-renowned research institutes: Quadram Institute, Earlham Institute, John Innes Centre and The Sainsbury Laboratory alongside the University of East Anglia (UEA) and Norfolk and Norwich University Hospitals. The Park hosts around 30,000 talented people, including 17,000 students, 3,000 researchers and clinicians, and over 115 companies. The outstanding reputation of our researchers is internationally recognised, with 10 of the Park's scientists in the top 1% of the "most highly cited" in the world.

Living in Norfolk

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Microbiome Technician

Applications are invited for a Microbiome Technician to join the Laboratory of Dr Hildebrand in the Gut Microbes and Health programme at Quadram Institute Bioscience (QIB), based in Norwich, UK.

Background:

How do gut bacteria colonize new human hosts and persist for decades with the same human? And how many fungi are present in human microbiomes? To answer these and follow up questions, the Hildebrand group received an ERC Starter grant that the post holder will work on in this project.

Our aim is to dissect these questions on a family centric cohort, PEARL-AGE (https://quadram.ac.uk/pearl-agestudy/).

The role:

We’re looking for an enthusiastic researcher interested in working with human samples, DNA extractions and sequencing library preparations (ilumina, PacBio, potentially ONT). In addition the candidate will also be involved in ongoing research within the group, such as biasing DNA extractions to improve overall throughput of current lab protocols as well as looking into mechanisms to reduce overall costs for these.

The Microbiome Technician will work on the EPYC ERC project and other related projects in the Hildebrand lab. The successful candidate and will develop skills in advanced microbiology techniques, sequencing technologies, culturing work with eukaryotes and prokaryotes and DNA extractions.

The ideal candidate:

Candidates should have an MRes in microbiology or a related discipline with previous experience working with microbiomes, DNA extractions, illumina and PacBio library preparations. Good communication and organisation skills with the ability to work independently are also required.

The post is expected to commence in early summer 2024.

Additional information:

Salary on appointment will be within the range £27,750 to £34,500 per annum depending on qualifications and experience. This is a full-time post for a contract of 6 months.

We are committed to equal opportunities and welcome applications from all sectors of society.  The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values.  To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

About the Quadram Institute:

The Quadram Institute is a new interdisciplinary research institute dedicated to understanding how food and microbes interact to promote health and prevent disease. Its mission is to deliver healthier lives through innovation in gut health, microbiology and food. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital and BBSRC, it brings together scientists and clinicians in a state-of-the-art building on the Norwich Research Park. This is one of Europe’s largest centres of life sciences and home of the John Innes Centre and The Earlham Institute. (https://quadram.ac.uk/).

The closing date for applications will be 22 February 2024

The Quadram Institute Bioscience is a registered charity (No. 1058499) and is an Equal Opportunities Employer.