Research scientist
Post Details
Job Title
Research scientist
Post Number
1004665
Closing Date
18 Jun 2024
Grade
SC6
Starting Salary
£35,300 - £43,750
Hours per week
37
Expected/Ideal Start Date
02 Sep 2024
Months Duration
46
Interview Date
28 Jun 2024

Job Description

Main Purpose of the Job

The successful candidate will be responsible for the running and development of Microphysiological systems (MPS) including Organ-on-a-Chip (OOAC) platforms.

This includes conducting MPS-based projects for academic and commercial research; developing advanced MPS and OOAC models to support QIB science in the area of food, microbiome and host interactions; providing training/supervision to QIB staff and students; liaising with MPS technical staff and suppliers, and QIB line managers; liaising with NRP biorepository team and QIB Human study team for access to human samples and generating organoids; ensuring Good Clinical Practice (GCP) and Ethical approvals are in place.

Key Relationships

The post-holder will work in the Food, Microbiome and Health Institute Strategic Programme and will be line-managed by Prof Nathalie Juge (Deputy Chief Scientific Officer).

Main Activities & Responsibilities

Percentage
To provide expertise and conduct projects based on the use of microphysiological systems (MPS) (including organ-on-chip) (academic and commercial research projects)
50
To develop advanced MPS models (co-culture with microbiome, immune cells,  organoids from different body sites, engineered cell models etc)
15
To liaise, supervise, and train (when appropriate) QIB users (staff and students) and collaborators 
10
To liaise with technical staff and suppliers and carry out horizon-scanning of new MPS 
5
To liaise with NRP Biorepository and QIB Human Study Team for relevant Ethical applications and access to human tissue and with QIB Lab managers
5
Be curator of cell/tissue culture room
5
Present their results internally at International Conferences
5
Contribute to the writing of scientific publications and reports
5

Person Profile

Education & Qualifications

Requirement
Importance
PhD in biological sciences
Essential

Specialist Knowledge & Skills

Requirement
Importance
Cell biology
Essential
Imaging
Essential
Organoid culture
Essential
Microbiology
Desirable
Organ-on-chip systems
Desirable

Relevant Experience

Requirement
Importance
Immunoassays
Essential
Immunohistochemistry
Essential
Microfluidic physiological systems
Essential
Intestinal organoid culture
Essential
Primary cell cultures
Essential
Experience of handling human samples
Desirable
Co-cultures with immune cells or microbiome
Desirable
Mammalian gene editing
Desirable
Experience of Ethics application
Desirable
Anaerobic gut microbe culture
Desirable
Flow cytometry
Desirable
Confocal microscopy
Desirable

Management and Leadership

Requirement
Importance
Experience of supervising, training and mentoring others
Essential
Management and leadership skills (resources, leadership, mentoring and training)
Essential

Interpersonal & Communication Skills

Requirement
Importance
Ability to work independently with minimum supervision
Essential
Excellent time management and organisational skills with an ability to meet objectives and deadlines
Essential
Ability to collaborate with internal and external stakeholders
Essential
Good interpersonal skills, with the ability to work well as part of a team
Essential
Excellent communication skills, both written and oral
Essential
High degree of commitment and motivation
Essential

Additional Requirements

Requirement
Importance
Attention to detail
Essential
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work
Essential
Ability to maintain confidentiality and security of information where appropriate
Essential
Willingness to work outside standard working hours when required
Essential
Promotes equality and values diversity
Essential
Ability to undertake occasional travel (national and international) related to collaborations and/or seminars
Essential
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
Essential

Who We Are

Quadram Institute Bioscience

The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health.

We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation.

The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on +44 (0)1603 450888 or nbi.recruitment@nbi.ac.uk.

For more information about working at Quadram Institute Bioscience, please click here.

Department

Food, Microbiome and Health

Group Details

The Juge Group focuses on the glycobiology of host-microbe interaction in the gut. The Group comprises two research assistants, three PhD students, three post-doctoral scientists and regularly host undergraduate students and visiting scientists. The Group has extensive collaborations on the Norwich Research Park and internationally.

Living in Norfolk

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Research Scientist

Applications are invited for a Research Scientist to join the Food, Microbiome and Health Institute Strategic Programme at the Quadram Institute Bioscience (QIB, Norwich, UK).

Background:

The Quadram Institute is an interdisciplinary research institute dedicated to understanding how food and microbes interact to promote health and prevent disease. Its mission is to deliver healthier lives through innovation in gut health, microbiology and food. A partnership between Quadram Institute Bioscience (QIB), the University of East Anglia (UEA), the Norfolk and Norwich University Hospital (NNUH) and BBSRC, it brings together scientists and clinicians in a state-of-the-art building on the Norwich Research Park (NRP). This is one of Europe’s largest centres of life sciences and home of the John Innes Centre and The Earlham Institute. (https://quadram.ac.uk/).

The role:

An exciting opportunity has arisen for a Research Scientist to contribute to the development and applications of microphysiological systems (MPS) including organ-on-chip technologies in support of the work carried out at QIB on the interaction between food, microbiome and the host. The successful candidate will benefit from a unique research environment and access to core facilities and expertise available at the QIB and opportunities for personal and career development. The successful candidate will contribute to a wide variety of projects and provide training to MPS platform users They will also contribute to the development of advanced MPS models.

The ideal candidate:

A PhD in Biological Sciences, previous research experience in the area of MPS and intestinal organoids are essential as is being competent in a variety of cell biology techniques including flow cytometry and microscopy. Experience of host-microbiota interactions and project management would be advantageous. The ideal candidate will have excellent organisational skills and a demonstrated ability to prioritise their workload and deliver work to deadlines. The successful candidate will ideally have a demonstrated ability to provide training to users in their area of expertise. The flexibility to work occasional out-of-hours and to travel nationally or internationally is also desirable.

Additional information:

Salary on appointment will be within the range £35,300 to £43,750 per annum depending on qualifications and experience. This is a full time, fixed term contract until 31 March 2028.
                                                                                                                                                        
This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options

Interviews will be held on 28 June 2024.

We are committed to equal opportunities and welcome applications from all sectors of society.  The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values.  To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

The closing date for applications will be 18 June 2024.

The Quadram Institute Bioscience is a registered charity (No. 1058499) and is an Equal Opportunities Employer.